生命数理科学分野

Unravel the mysteries of biological morphogenesis with a comprehensive framework that connects experimental observations, hypothesis formulation, simulations, and inference computations. This video showcases how these elements integrate to provide insights into the mechanisms driving tissue folding and 3D shape formation. Key Topics: Experimental observations as a foundation for modeling morphogenesis Hypothesis-driven simulations of tissue deformation Biological relevance to neural tube formation, intestinal villi, and beetle horn development Inference computations revealing the role of spatial patterns in differential growth This approach bridges theory and experiment, advancing our understanding of developmental biology and bioengineering applications. References: Yasuhiro Inoue, Makoto Suzuki, Tadashi Watanabe, Naoko Yasue, Itsuki Tateo, Taiji Adachi, Naoto Ueno Mechanical roles of apical constriction, cell elongation, and cell migration during neural tube formation in Xenopus, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2016) https://doi.org/10.1007/s10237-016-0794-1 Yasuhiro Inoue, Tadashi Watanabe, Satoru Okuda, Taiji Adachi Mechanical role of the spatial patterns of contractile cells in invagination of growing epithelial tissue, DEVELOPMENT, GROWTH & DIFFERENTIATION (2017) https://doi.org/10.1111/dgd.12374 Yasuhiro Inoue, Itsuki Tateo, Taiji Adachi Epithelial tissue folding pattern in confined geometry, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2020) https://doi.org/10.1007/s10237-019-01249-8 Kentaro Morikawa, Daichi Kuroda, Yasuhiro Inoue Impact of environmental asymmetry on epithelial morphogenesis, Scientific Reports (2022) https://doi.org/10.1038/s41598-022-15343-y Kentaro Morikawa, Shinichi Morita, Kazuki Sakura, Akiteru Maeno, Hiroki Gotoh, Teruyuki Niimi, Yasuhiro Inoue Unveiling the role of differential growth in 3D morphogenesis: An inference method to analyze area expansion rate distribution in biological systems, Journal of Theoretical Biology (2023) https://doi.org/10.1016/j.jtbi.2023.111650 Kentaro Morikawa, Yasuhiro Inoue Computational mechanics simulations on epithelial folding (Strengths, insights, and future challenges), Journal of Biomechanical Science and Engineering (2024) https://doi.org/10.1299/jbse.23-00562 Github: https://github.com/yasuhiroinoue https://github.com/k-morikawa68/ Visit our GitHub and explore the papers linked in the description for more details. Supported by MEXT KAKENHI Grant Numbers JP20H05947, JP15H05861.

Morikawa, K., Kuroda, D. & Inoue, Y. Impact of environmental asymmetry on epithelial morphogenesis. Sci Rep 12, 11326 (2022). https://doi.org/10.1038/s41598-022-15343-y https://github.com/k-morikawa68/SH_Simulator Illustrations used in this video are sourced from Freepik: Intestinal wall structure illustration by brgfx Human brain illustration by rawpixel.com Life cycle of a monarch butterfly illustration by brgfx White fabric texture photo by vector_corp Isometric genetic engineering set illustration by macrovector Special thanks to these creators for their wonderful work.

Mimura, T and Inoue Y., Cell-center-based model for simulating three-dimensional monolayer tissue deformation, Journal of Theoretical Biology, Vol. 571, 11560 https://doi.org/10.1016/j.jtbi.2023.111560 https://github.com/TomohiroMimura/CellCenterModel

2022年11月5～6日 サイエンスアゴラ2022に出展しました。 https://www.jst.go.jp/sis/scienceagora/2022/ 学術変革領域研究（A)「素材によって変わる、『体』の建築工法」（からだ工務店） https://www.architect-bio.info/

京都大学　第19回MACSコロキウム https://ocw.kyoto-u.ac.jp/course/1106/ 「形態形成の多細胞力学シミュレーション」 井上 康博（工学研究科 教授） 2022年04月18日（月） Zoomオンライン配信 00:00 | はじめに 00:21 | 計算力学 10:32 | 多細胞力学モデル 19:12 | 多細胞力学シミュレーション 35:20 | 第１段階：真似る（control model) 37:52 | 第２段階：確かめる 40:44 | 第３段階：予測する（仮想実験） 44:40 | 今後の展開とまとめ

Morikawa, K., Kuroda, D. & Inoue, Y. Impact of environmental asymmetry on epithelial morphogenesis. Sci Rep 12, 11326 (2022). https://doi.org/10.1038/s41598-022-15343-y Simulation code is distributed at https://github.com/k-morikawa68/SH_Simulator

Morikawa, K., Kuroda, D. & Inoue, Y. Impact of environmental asymmetry on epithelial morphogenesis. Sci Rep 12, 11326 (2022). https://doi.org/10.1038/s41598-022-15343-y Simulation code is distributed at https://github.com/k-morikawa68/SH_Simulator

Morikawa, K., Kuroda, D. & Inoue, Y. Impact of environmental asymmetry on epithelial morphogenesis. Sci Rep 12, 11326 (2022). https://doi.org/10.1038/s41598-022-15343-y Simulation code is distributed at https://github.com/k-morikawa68/SH_Simulator